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  • br G Dilorenzo et al br A prospective study


    G. Dilorenzo, et al.
    A prospective study, including also a control group of healthy pa-tients, is necessary to investigate the effect of BPE on the risk of single breast cancer subtypes.
    5. Conclusions
    BPE could play a crucial role as an imaging bridge to molecular breast cancer subtype allowing an additional risk stratification in the field of breast MRI and targeted screening tests. Luminal B (HER2-) tumors could prevail in case of mild BPE on CE-MRI examinations and TN tumors in patients with marked BPE. Further studies on larger series are needed to confirm this hypothesis.
    Conflicts of interest
    The authors declare that there are no conflicts of interest regarding the publication of this paper.
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    Contents lists available at ScienceDirect
    Gynecologic Oncology
    Breastfeeding factors and risk of epithelial ovarian cancer☆
    Francesmary Modugno a,b, , Sharon L. Goughnour b, Danielle Wallack c, Robert P. Edwards b, Kunle Odunsi d, Joseph L. Kelley b, Kirsten Moysich d, Roberta B. Ness e, Maria Mori Brooks c
    a Womens Cancer Research Program, Magee-Womens Research Institute and UPMC Hillman Cancer Center, USA
    b Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    c Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
    d Roswell Park Cancer Institute, Buffalo, NY, USA
    e University of Texas School of Public Health, Houston, TX, USA
    • Breastfeeding for as few as 3 months – the duration of a maternity leave – is associated with reduced ovarian cancer risk.
    • This association decreases over time but persists for more than 30 years.
    • Longer duration, greater number of offspring nursed, and earlier age at first breastfeeding associate with reduced risk.
    • This association is similar in magnitude and duration to that observed for oral contraceptive use and bearing children.
    Article history:
    Epithelial ovarian cancer
    Case-control study
    Epithelial ovarian cancer 
    Objective. Previous studies suggest that breastfeeding reduces epithelial ovarian cancer (EOC) risk. However, the effects of age, timing and episode details on the EOC-breastfeeding relationship have not been examined. The objective of this study was to examine the association between breastfeeding factors and epithelial ovarian can-cer.
    Methods. We examined breastfeeding factors among parous women in a population-based, case-control study conducted in Pennsylvania, Ohio, and New York from 2003 to 2008. We compared 689 incident EOC cases to 1572 community controls. Multivariable unconditional logistic regression was used to calculate odds ra-tios (ORs) and 95% confidence intervals (CIs) associated with breastfeeding patterns adjusting for potential con-founders.