• Cohort studies have shown that the

  2019-08-16

  

  Cohort studies have shown that the incidence of lung cancer presents a significant positive association with estimated vehicle emissions of particulate matter—PM10 or PM2.5—as well as with chronic exposure to those pollutants [8,13,44,45]. That lends support to evidence that the inhalation of carcin

• In the current investigation we observed no

  2019-08-11

  

  In the current investigation we observed no evidence of racial differences in sepsis incidence after cancer survival. In contrast, several studies have suggested that Blacks suffer poorer outcomes in cancer survival due to delays, receipt, and adherence to cancer treatment [[51], [52], [53], [54], [

• Finally we investigated whether serum CRP

  2019-08-11

  

  Finally, we investigated whether serum CRP levels were associated with incidents of cancer using multivariable Cox regression analysis and the results are summarized in Table 4. Among the 2753 study participants, a total of 177 cases were identified during the follow-up as having experienced cancer.

• In the Emb LPD murine model

  2019-08-11

  

  In the Emb-LPD murine model, decreased levels of insulin in blood and branched-chain Temozolomide (BCAA) in uterine luminal fluid (ULF) were detected at the time of blastocyst formation and coincided with a reduced blastocyst mTORC1 signal mediated through these metabolites [8]. In vitro experiments

• JNJ-42153605 br Conclusions br Transparency document br Ackn

  2019-07-30

  

  Conclusions Transparency document Acknowledgments This work was supported by the Michael J Fox Foundation (Grant no. 12080) for Parkinson's research and the Telethon Foundation (Grant no. GGP12237). Introduction According to the latest survey, over 10% of human tumors are caused by vira

• Emerging data demonstrate that epigenetic mechanisms regulat

  2019-07-30

  

  Emerging data demonstrate that epigenetic mechanisms regulate the innate and adaptive immune response, including macrophages, T lymphocytes and microglia. For instance, tri-methylation of histone 3 lysine 27 (H3K27) leads to an increased inflammatory phenotype of macrophages and microglia, also know

• br Methods and materials br Results br Discussion Earlier

  2019-07-30

  

  Methods and materials Results Discussion Earlier studies showed that TOP2A always aberrantly expressed in various cancers and associated with tumor progression, such as breast cancer, prostate cancer, colorectal cancer, etc. Tarpgaard LS et al. reported TOP2A was associated with drug resist

• In summary cardiomyocytes the main effectors of cardiac cont

  2019-07-24

  

  In summary, cardiomyocytes, the main effectors of cardiac contraction, play a critical role in a sequence of events induced by chronic cardiac pressure overload triggering concentric hypertrophy, then inducing a heart status recapitulating criteria of HFpEF. We underscored the relationship between e

• Hox gene expression is commonly regulated via several mechan

  2019-07-24

  

  Hox gene expression is commonly regulated via several mechanisms including microRNAs action, methylation and transcription factor-mediated regulation [44]. In our cell model, the expression of HoxA5 was not dependent upon either promoter de-methylation nor by microRNAs known to have HoxA5 as target

• In various species AOX has been

  2019-07-11

  

  In various species, AOX has been reported to become activated by metabolites such as pyruvate [3,[5], [6], [7]] and other organic acids [8,9], that may accumulate under conditions of RC overload or inhibition, or in response to specific metabolic stresses. In some taxa the aRC enzymes have also been

• br Mitochondrial quality control An overview br Mitochondria

  2019-07-11

  

  Mitochondrial quality control: An overview Mitochondrial quality control in the healthy and diseased heart: Maintenance, reprogramming, and response to injury mQC has been a topic of growing interest in the field of cardiology. While important progress has been made, specifically in the study

• br Animal models transgenic models

  2019-07-08

  

  Animal models: transgenic models requiring triggers to induce AIH-like disease Most spontaneous transgenic AIH models are dependent on deficiencies in either induction or maintenance of general or liver-specific immune tolerance mechanisms. However, although risk factors, such as the HLA haplotyp

• br Mechanisms of bile formation The bile consists of

  2019-07-08

  

  Mechanisms of bile formation The bile consists of 95% of water in which several exogenous compounds, including drugs, xenobiotics and environmental toxins, are dissolved to be discharged together with endogenous components, like bile acids, conjugated bilirubin, lipids (mainly phosphatidylcholine

• If we accept that the

  2019-07-08

  

  If we accept that the contribution of the portal vein to hepatic blood flow decreases and that of the hepatic artery increases with increasing size of the mammal (Fig. 4F), it is tempting to speculate that the increased arterial supply serves perfusion of the larger liver lobules with longer portoce

• The mitochondrial defects in BAT

  2019-07-08

  

  The mitochondrial defects in BAT of MTERF4-FAT-KO mice are reminiscent of those found in heart of cardiac-specific MTERF4 knockout mice, which show reduced assembly and activity of OxPhos complexes I, III, IV and V, as well as low content of mtDNA-encoded proteins and reduced levels of some nDNA-enc

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