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  • br Accepted date br Please cite this article as

    2019-09-24


    Accepted date: 
    Please cite this article as: Reyna Aguilar Quispe DDS, MSc , Ana Carolina Cunha Rodrigues DDS ,
    Ana Maria Greff Buaes DDS , Ana Lucia Alvares Capelozza DDS, MSc, PhD , Cassia« Maria Fischer Rubira DDS, MSc, PhD , Paulo Sergio« da Silva Santos DDS, MSc, PhD , A CASE-CONTROL STUDY OF DENTAL ABNORMALITIES AND DENTAL MATURITY IN
    CHILDHOOD CANCER SURVIVORS, Oral Surg Oral Med Oral Pathol Oral Radiol (2019), doi:
    This is a PDF Þle of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it Lycopene is published in its Þnal form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
    ACCEPTED MANUSCRIPT
    A CASE-CONTROL STUDY OF DENTAL ABNORMALITIES AND DENTAL MATURITY IN CHILDHOOD CANCER SURVIVORS
    Original Research Article
    Reyna Aguilar Quispe, DDS, MSc,a Ana Carolina Cunha Rodrigues, DDS,b Ana Maria Greff Buaes, DDS,c Ana Lucia Alvares Capelozza, DDS, MSc, PhD,a Cássia Maria Fischer Rubira, DDS, MSc, PhD,a Paulo Sérgio da Silva Santos, DDS, MSc, PhDa
    aDepartment of Surgery, Stomatology, Pathology and Radiology of Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil
    bDepartament of Dentistry, Endodontics and Dental Materials of Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil
    cDepartament of Dentistry of Childhood Cancer Institute, Porto Alegre, Rio Grande do Sul, Brazil
    The authors declare that there is no conflict of interest.
    This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001.
    Correspondence:
    Reyna Aguilar Quispe, Department of Surgery, Stomatology, Pathology and
    São Paulo, Brazil.
    E-mail: [email protected]
    ABSTRACT
    Objective: To evaluate dental abnormalities and dental maturity in permanent dentition of childhood cancer survivors (CCS) and to compare them with healthy individuals. r> Study design: A retrospective, case-control study, with convenience sampling, evaluated 111 panoramic radiographs (PR) of CCS compared to 111 PR of healthy individuals matched for age and gender. Dental anomalies were
    ACCEPTED MANUSCRIPT
    associated with age of cancer diagnosis and type of antineoplastic treatment.
    Dental maturity was assessed using the Demirjian method.
    Results: A higher prevalence of microdontia, hypodontia and dental root anomalies were present in CCS when compared to healthy individuals (p < 0.05). CCS were the only individuals with 10 or >10 dental anomalies when compared to healthy individuals. Microdontia was the only dental anomaly associated with an age of cancer diagnosis younger than 71 months of age (p < 0.05). Impacted teeth were associated with CCS bryophytes underwent multimodal cancer treatment (p < 0.001). Dental maturity did not present a significant statistical difference between CCS and healthy individuals (p > 0.05).
    Conclusions: The CCS had a higher prevalence of dental anomalies without dental maturity alteration when compared to healthy individuals. Age of cancer diagnosis and type of treatment can influence the prevalence of some dental abnormalities.
    Keywords: Chemotherapy, radiotherapy, children, dental abnormalities, dental maturity.
    STATEMENT OF CLINICAL RELEVANCE
    This case-control study provides information about late effects of antineoplastic